Speed of Intracranial Clot Lysis With Intravenous Tissue Plasminogen Activator Therapy
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چکیده
منابع مشابه
Speed of Intracranial Clot Lysis With Intravenous Tissue Plasminogen Activator Therapy
Background—Arterial recanalization precedes clinical improvement or may lead to hemorrhage or reperfusion injury. Speed of clot lysis was not previously measured in human stroke. Methods and Results—Transcranial Doppler (TCD) and the National Institutes of Health Stroke Scale (NIHSS) were used to monitor consecutive patients receiving intravenous tissue plasminogen activator (tPA), before tPA b...
متن کاملSpeed of intracranial clot lysis with intravenous tissue plasminogen activator therapy: sonographic classification and short-term improvement.
BACKGROUND Arterial recanalization precedes clinical improvement or may lead to hemorrhage or reperfusion injury. Speed of clot lysis was not previously measured in human stroke. METHODS AND RESULTS Transcranial Doppler (TCD) and the National Institutes of Health Stroke Scale (NIHSS) were used to monitor consecutive patients receiving intravenous tissue plasminogen activator (tPA), before tPA...
متن کاملMicrobubble administration accelerates clot lysis during continuous 2-MHz ultrasound monitoring in stroke patients treated with intravenous tissue plasminogen activator.
BACKGROUND AND PURPOSE We sought to evaluate the effects of administration of microbubbles (MBs) on the beginning, speed, and degree of middle cerebral artery (MCA) recanalization during systemic thrombolysis and continuous 2-MHz pulsed-wave transcranial Doppler (TCD) monitoring. METHODS We evaluated 111 patients with acute stroke attributable to MCA occlusion treated with intravenous tissue ...
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In an attempt to investigate the effect of tissue plasminogen activator in the resolution of intracerebral haematoma an experimental model of intracerebral haematoma was designed in the cat. A total of 24 adult cats were studied. Intracerebral hematomas were provoked by stereotaxically injecting 0.2 ml of dotted human blood into the left frontal lobe. Control animals received 0.2 ml of normal s...
متن کاملInhibition of Clot Lysis and Decreased Binding of Tissue-Type Plasminogen Activator as a Consequence of Clot Retraction
Tissue-type plasminogen activator (t-PA) is less active in vivo and in vitro against clots that are enriched in platelets, even at therapeutic concentrations. The release of radioactivity from ‘El-fibrin-labeled clots was decreased by 47% 6 hours after the addition of t-PA 400 U/mL when formed in plateletrich versus platelet-poor plasma. This difference was not due to the release of plasminogen...
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ژورنال
عنوان ژورنال: Circulation
سال: 2001
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.103.24.2897